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NasoNeb

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Compounds and sinusitis

Specially formulated nebulization compounds have emerged as a widely prescribed, innovative and advanced approach to treating acute and chronic rhinosinusitis.

Advantages include:

  • Target the specific cause of the inflammation and infection

  • Reduce or eliminate systemic side effects associated with oral medications

  • Directly impact organisms found in the mucous

  • Diminish or remove the susceptibility of superbugs, increasing likelihood of remission

  • Take a multimodal approach to treat both the cause and symptoms simultaneously

Optimized drug delivery to the nasal and paranasal sinus cavities

The advantages of specially compounded medications for nasal inhalation are believed to be (1) their ability to provide (through intranasal delivery) a greater concentration of medications directly into the target organ, the sinonasal cavities, reducing systemic complications; (2) the availability of an additional treatment option for current chronic patients that have not responded to or are unable to tolerate oral and intravenous treatment.

Differences between healthy and infected sinuses

In a recent Stanford University study, it was found that postsurgical patients treated with culture-directed nebulized antibiotic therapy demonstrated a significant (300%+) increase in their infection-free intervals compared with oral medications, and indicated an overwhelming preference for nebulized over systemic therapy.

Additional benefits have been reported in measurements of drug concentration in blood versus sinus mucosa after nebulized drug administration (3), where very low concentration in blood was found compared with high concentration in ethmoidal and maxillary mucosa.

  1. Guevara J, Pascual B, et al.: Ambulatory aerosol therapy in the treatment of chronic pathology in the ORL sphere. An Otorrinolaringol Iber 1991, 18:231–238. Determined the mass median diameter particle size to be less than 5 μm necessary to treat sinus infections with nebulized medication.

  2. Vaughan W, Carvahlo G: Nebulized antibiotics for acute infections in chronic sinusitis [abstract]. Otolaryngol Head Neck Surg 2001, in press. Effectiveness of specially compounded antibiotics for nasal inhalation determined by change in infection-free period.

  3. Haruna S, Ozawa M, et al.: Nebulizer therapy after endoscopic sinus surgery— application of erythromycin nebulizer therapy. Dept. of Oto, Jikei University School of Med. Curriculum material and presentations.